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注意：仅列出部分参考文献，下载原文获取全部文献信息。Amino acids as regulators of gene expression in mammals: Molecular mechanisms
Alain Bruhat et al.
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Identification of a Novel Amino Acid Response Pathway Triggering ATF2 Phosphorylation in Mammals
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ATF4-dependent transcription mediates signaling of amino acid limitation
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Hepatic insulin resistance induced by prenatal alcohol exposure is associated with reduced PTEN and TRB3 acetylation in adult rat offspring
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Deprivation of protein or amino acid induces C/EBP β synthesis and binding to amino acid response elements, but its action is not an absolute requirement for enhanced transcription
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PI3K activates negative and positive signals to regulate TRB3 expression in hepatic cells
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TRB3 blocks adipocyte differentiation through the inhibition of C/EBPβ transcriptional activity
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MOLECULAR AND CELLULAR BIOLOGY (2007)
TRB3 protects cells against the growth inhibitory and cytotoxic effect of ATF4
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EXPERIMENTAL CELL RESEARCH (2007)
Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells
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GENES & DEVELOPMENT (2007)
A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor
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MOLECULAR AND CELLULAR BIOLOGY (2007)
TRB3 inhibits the transcriptional activation of stress-regulated genes by a negative feedback on the ATF4 pathway
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ATF2 is required for amino acid-regulated transcription by orchestrating specific histone acetylation
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NUCLEIC ACIDS RESEARCH (2007)
Activation of the ATF3 gene through a co-ordinated amino acid-sensing response programme that controls transcriptional regulation of responsive genes following amino acid limitation
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BIOCHEMICAL JOURNAL (2007)
Effect of TRB3 on insulin and nutrient-stimulated hepatic p70 S6 kinase activity
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism
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TRB3 is a PI 3-kinase dependent indicator for nutrient starvation
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Chronic ethanol intake impairs insulin signaling in rats by disrupting akt association with the cell membrane - Role of TRB3 in inhibition of Akt/protein kinase B activation
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The functional Q84R polymorphism of mammalian tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy
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Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores
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CELL METABOLISM (2005)
TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death
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Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex
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SCIENCE (2005)
Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Amino acid deprivation induces the transcription rate of the human asparagine synthetase gene through a timed program of expression and promoter binding of nutrient-responsive basic region/leucine zipper transcription factors as well as localized histone acetylation
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Human tribbles, a protein family controlling mitogen-activated protein kinase cascades
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Mouse NIPK interacts with ATF4 and affects its transcriptional activity
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TRB3:: A tribbles homolog that inhibits Akt/PKB activation by insulin in liver
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An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
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Differences in the molecular mechanisms involved in the transcriptional activation of the CHOP and asparagine synthetase genes in response to amino acid deprivation or activation of the unfolded protein response
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Nutritional control of mRNA stability is mediated by a conserved AU-rich element that binds the cytoplasmic shuttling protein HuR
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The immuno suppress ant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation
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MOLECULAR AND CELLULAR BIOLOGY (2002)
ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Regulated translation initiation controls stress-induced gene expression in mammalian cells
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Amino acids control mammalian gene transcription:: Activating transcription factor 2 is essential for the amino acid responsiveness of the CHOP promoter
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Perk is essential for translational regulation and cell survival during the unfolded protein response
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