期刊
PLOS ONE
卷 5, 期 6, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0010943
关键词
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资金
- U.S. National Institutes of Health [AG09464, R01MH081164, R21HD065290]
- Fisher Center for Alzheimer's Disease Research Foundation
- F.M. Kirby Foundation, Inc.
- Lowe Foundation (Erma Lowe Laboratory for Alzheimer's Disease Research)
- Crystal Charity Ball Program for the Prevention of Complications in Children with Down's Syndrome
- Van Beber Family
- David M. Crowley Foundation
beta-amyloid levels are elevated in Down syndrome (DS) patients throughout life and are believed to cause Alzheimer's disease (AD) in adult members of this population. However, it is not known if beta-amyloid contributes to intellectual disability in younger individuals. We used a gamma-secretase inhibitor to lower beta-amyloid levels in young mice that model DS. This treatment corrected learning deficits characteristic of these mice, suggesting that beta-amyloid-lowering therapies might improve cognitive function in young DS patients.
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