期刊
PLOS ONE
卷 5, 期 5, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0010681
关键词
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资金
- Defence Advanced Research Projects Agency (DARPA)
- Medical Research Council [G0601490]
- Association of Anaesthetists of Great Britain and Ireland
- Intensive Care Society
- Sir Halley Stewart Trust
- John Caudwell
- BOC Medical (now Linde Gas Therapeutics)
- Lilly Critical Care
- London Clinic
- Smiths Medical
- Deltex Medical
- Rolex Foundation
- United Kingdom Department of Health's National Institute for Health Research
- British Heart Foundation [RG/07/004/22659, PS/02/002/14893] Funding Source: researchfish
- Medical Research Council [G0601490] Funding Source: researchfish
Many disease states are associated with regional or systemic hypoxia. The study of healthy individuals exposed to high-altitude hypoxia offers a way to explore hypoxic adaptation without the confounding effects of disease and therapeutic interventions. Using P-31 magnetic resonance spectroscopy and imaging, we investigated skeletal muscle energetics and morphology after exposure to hypobaric hypoxia in seven altitude-naive subjects (trekkers) and seven experienced climbers. The trekkers ascended to 5300 m while the climbers ascended above 7950 m. Before the study, climbers had better mitochondrial function (evidenced by shorter phosphocreatine recovery halftime) than trekkers: 16+/-1 vs. 22+/-2 s (mean +/- SE, p<0.01). Climbers had higher resting [Pi] than trekkers before the expedition and resting [Pi] was raised across both groups on their return (PRE: 2.6+/-0.2 vs. POST: 3.0+/-0.2 mM, p<0.05). There was significant muscle atrophy post-CXE (PRE: 4.7+/-0.2 vs. POST: 4.5+/-0.2 cm(2), p<0.05), yet exercising metabolites were unchanged. These results suggest that, in response to high altitude hypoxia, skeletal muscle function is maintained in humans, despite significant atrophy.
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