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Juan M. Garcia-Martinez et al.
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G. Kroemer et al.
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Carson C. Thoreen et al.
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Edmond Y. W. Chan et al.
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Mondira Kundu et al.
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Rottlerin induces autophagy and apoptotic cell death through a PKC-δ-independent pathway in HT1080 human fibrosarcoma cells -: The protective role of autophagy in apoptosis
Kyoung-Sub Song et al.
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Kanou Kojima et al.
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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
Juan M. Garcia-Martinez et al.
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Lorenzo Galluzzi et al.
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MTORCI inhibitors: is temsirolimus in renal cancer telling us how they really work?
C. Le Tourneau et al.
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NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations
Violeta Serra et al.
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In vitro trypanocidal activity of the anti-helminthic drug niclosamide
Karin Merschiohann et al.
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Re-evaluating the Roles of Proposed Modulators of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling
Xuemin Wang et al.
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Atg8 controls phagophore expansion during autophagosome formation
Zhiping Xie et al.
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The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae
Heesun Cheong et al.
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Global disruption of cell cycle progression and nutrient response by the antifungal agent amiodarone
Yong-Qiang Zhang et al.
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Regulation of mTOR and S6K1 activation by the nPKC isoforms, PKCε and PKCε in adult cardiac muscle cells
Phillip C. Moschella et al.
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Small molecule regulators of autophagy identified by an image-based high-throughput screen
Lihong Zhang et al.
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Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53
Chung-Han Lee et al.
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Neuroprotective effect of protein kinase Cδ inhibitor rottlerin in cell culture and animal models of Parkinson's disease
Danhui Zhang et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex
Bruno D. Fonseca et al.
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The proline-rich akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1
Noriko Oshiro et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models
Sovan Sarkar et al.
NATURE CHEMICAL BIOLOGY (2007)
Methods for monitoring autophagy from yeast to human
Daniel J. Klionsky et al.
AUTOPHAGY (2007)
Perhexiline
Houman Ashrafian et al.
CARDIOVASCULAR DRUG REVIEWS (2007)
Rottlerin: an inappropriate and ineffective inhibitor of PKC delta
Stephen P. Soltoff
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Potential therapeutic applications of autophagy
David C. Rubinsztein et al.
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The mTOR pathway in the control of protein synthesis
Xuemin Wang et al.
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Identifying off-target effects and hidden phenotypes of drugs in human cells
Marnie L. MacDonald et al.
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Qi-Wen Fan et al.
CANCER CELL (2006)
In yeast, loss of Hog1 leads to osmosensitivity of autophagy
T Prick et al.
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TOR signaling in growth and metabolism
S Wullschleger et al.
CELL (2006)
TOR signaling in growth and metabolism
Stephan Wullschleger et al.
CELL (2006)
Ribosomal protein S6 phosphorylation: from protein synthesis to cell size
Igor Ruvinsky et al.
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Khalid Abozguia et al.
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Elevated phosphorylation and activation of PDK-I/AKT pathway in human breast cancer
HJ Lin et al.
BRITISH JOURNAL OF CANCER (2005)
mTOR•RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
RC Hresko et al.
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Molecular mechanism and regulation of autophagy
YP Yang et al.
ACTA PHARMACOLOGICA SINICA (2005)
Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins
XM Wang et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
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The role of autophagy in cancer development and response to therapy
Y Kondo et al.
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Metabolic manipulation in ischaemic heart disease, a novel approach to treatment
L Lee et al.
EUROPEAN HEART JOURNAL (2004)
Autophagy: a regulated bulk degradation process inside cells
T Yoshimori
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Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
OJ Shah et al.
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Role and regulation of starvation-induced autophagy in the Drosophila fat body
RC Scott et al.
DEVELOPMENTAL CELL (2004)
Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway
TE Rusten et al.
DEVELOPMENTAL CELL (2004)
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
LS Harrington et al.
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Regulation and role of autophagy in mammalian cells
AJ Meijer et al.
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Apoptosis, autophagy, and more
RA Lockshin et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2004)
TSC2 mediates cellular energy response to control cell growth and survival
K Inoki et al.
CELL (2003)
Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR
HB Zhang et al.
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Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner
AF Castro et al.
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Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
AR Tee et al.
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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
K Inoki et al.
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Ca2+-independent protein kinase C activity is required for α1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes
LJ Wang et al.
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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
A Garami et al.
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Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
AR Tee et al.
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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
K Inoki et al.
NATURE CELL BIOLOGY (2002)
A quantitative molecular model for modulation of mammalian translation by the eIF4E-binding protein 1
MM Karim et al.
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Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine
D Curman et al.
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A ubiquitin-like system mediates protein lipidation
Y Ichimura et al.
NATURE (2000)
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
Y Kabeya et al.
EMBO JOURNAL (2000)
The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway
T Kirisako et al.
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Tor-mediated induction of autophagy via an Apg1 protein kinase complex
Y Kamada et al.
JOURNAL OF CELL BIOLOGY (2000)