4.6 Article

2009 Swine-Origin Influenza A (H1N1) Resembles Previous Influenza Isolates

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PLOS ONE
卷 4, 期 7, 页码 -

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PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0006402

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  1. NIGMS NIH HHS [R01 GM083873, R01-GM083873] Funding Source: Medline
  2. NLM NIH HHS [R01 LM006845-10, R01 LM006845] Funding Source: Medline

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Background: In April 2009, novel swine-origin influenza viruses (S-OIV) were identified in patients from Mexico and the United States. The viruses were genetically characterized as a novel influenza A (H1N1) strain originating in swine, and within a very short time the S-OIV strain spread across the globe via human-to-human contact. Methodology: We conducted a comprehensive computational search of all available sequences of the surface proteins of H1N1 swine influenza isolates and found that a similar strain to S-OIV appeared in Thailand in 2000. The earlier isolates caused infections in pigs but only one sequenced human case, A/Thailand/271/2005 (H1N1). Significance: Differences between the Thai cases and S-OIV may help shed light on the ability of the current outbreak strain to spread rapidly among humans.

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