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A high viral burden predicts the loss of CD8 T-cell responses specific for subdominant Gag epitopes during chronic human immunodeficiency virus infection
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Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover
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Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major
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Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8+ T cell responses
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Multifunctional human immunodeficiency virus (HIV) gag-specific CD8+ T-cell responses in rectal mucosa and peripheral blood mononuclear cells during chronic HIV type 1 infection
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JOURNAL OF VIROLOGY (2007)
Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes
Isobella Honeyborne et al.
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Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression
Jonah B. Sacha et al.
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CD8 T-cell recognition of multiple epitopes within specific gag regions is associated with maintenance of a low steady-state viremia in human immunodeficiency virus type 1-seropositive patients
Christof Geldmacher et al.
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CD8(+) T-cell responses to different HIV proteins have discordant associations with viral load
Photini Kiepiela et al.
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Lack of mucosal immune reconstitution during prolonged treatment of acute and early HIV-1 infection
Saurabh Mehandru et al.
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Viral suppression and immune restoration in the gastrointestinal mucosa of human immunodeficiency virus type 1-infected patients initiating therapy during primary or chronic infection
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HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells
Michael R. Betts et al.
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Interactive association of proviral load and IFN-γ-secreting T cell responses in HIV-1C infection
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Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1
J Martinez-Picado et al.
JOURNAL OF VIROLOGY (2006)
Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control
R Zuñiga et al.
JOURNAL OF VIROLOGY (2006)
Cutting edge: Gut microenvironment promotes differentiation of a unique memory CD8 T cell population
D Masopust et al.
JOURNAL OF IMMUNOLOGY (2006)
Intracellular cytokine optimization and standard operating procedure
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Testing the equality of two Poisson means using the rate ratio
HKT Ng et al.
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HIV evolution: CTL escape mutation and reversion after transmission
AJ Leslie et al.
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Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: changes after antiretroviral therapy
A Harari et al.
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Abundant expression, of granzyme A, burt not perforin, in granules of CD8+ T cells in GALT:: Implications for immune control of HIV-1 infection
BL Shacklett et al.
JOURNAL OF IMMUNOLOGY (2004)
Increased HIV-1 mucosal replication is associated with generalized mucosal cytokine activation
I McGowan et al.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2004)
Sensitive and viable identification of antigen-specific CD8+T cells by a flow cytometric assay for degranulation
MR Betts et al.
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Optimization of methods to assess human mucosal T-cell responses to HIV infection
BL Shacklett et al.
JOURNAL OF IMMUNOLOGICAL METHODS (2003)
Trafficking of human immunodeficiency virus type 1-specific CD8+ T cells to gut-associated lymphoid tissue during chronic infection
BL Shacklett et al.
JOURNAL OF VIROLOGY (2003)
Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load
MM Addo et al.
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Presence of HIV-1 gag-specific IFN-γ+IL-2+ and CD28+IL-2+ CD4 T cell responses is associated with nonprogression in HIV-1 infection
MJ Boaz et al.
JOURNAL OF IMMUNOLOGY (2002)
Most murine CD8+ intestinal intraepithelial lymphocytes are partially but not fully activated T cells
HC Wang et al.
JOURNAL OF IMMUNOLOGY (2002)
Magnitude of functional CD8(+) T-cell responses to the Gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasma
BH Edwards et al.
JOURNAL OF VIROLOGY (2002)
Analysis of total human immunodeficiency virus (HIV)-specific CD4+ and CD8+ T-cell responses:: Relationship to viral load in untreated HIV infection
MR Betts et al.
JOURNAL OF VIROLOGY (2001)
Cytotoxic T-cell abundance and virus load in human immunodeficiency virus type 1 and human T-cell leukaemia virus type 1
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PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2001)
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