期刊
PLATELETS
卷 20, 期 6, 页码 441-444出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/09537100903096684
关键词
Platelets; CD40L; sCD40L; protease; MMP-2
Platelets are the major source of soluble CD40 ligand (sCD40L) in the blood. It has been demonstrated that CD40L is cleaved from the surface of activated platelets to release sCD40L. However, the enzyme involved in sCD40L shedding has not been identified yet. Using a panel of pharmacological inhibitors of serine, cysteine, aspartate, or metalloproteinases, preliminary evidence is presented for the hypothesis that matrix metalloproteinase-2 (MMP-2) might be the protease, primarily responsible for CD40L cleavage from platelet surface.
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