期刊
PLASMID
卷 70, 期 1, 页码 42-51出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.plasmid.2013.02.001
关键词
Plasmid replication; Partitioning; Conjugation; Staphylococcus aureus
资金
- National Health and Medical Research Council of Australia [APP1030003]
Plasmid pSK41 is a large, low-copy-number, conjugative plasmid from Staphylococcus aureus that is representative of a family of staphylococcal plasmids that confer multiple resistances to a wide range of antimicrobial agents. The plasmid consists of a conserved plasmid backbone containing the genes for plasmid housekeeping functions, which is punctuated by copies of IS257 that flank a Tn4001-hybrid structure and cointegrated plasmids that harbour resistance genes. This review summarises the current understanding of the biology of pSK41, focussing on the systems responsible for its replication, maintenance and transmission, and their regulation. (C) 2013 Elsevier Inc. All rights reserved.
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