期刊
WORLD JOURNAL OF UROLOGY
卷 33, 期 7, 页码 955-964出版社
SPRINGER
DOI: 10.1007/s00345-015-1561-0
关键词
Focal therapy; Prostate cancer; Minimally invasive therapy; High-intensity focussed ultrasound; HIFU; Cryotherapy; Histology; Pathology; Trial design
资金
- Medical Research Council (UK)
- Pelican Cancer Foundation Charity
- Prostate Cancer UK
- St Peters Trust Charity
- Prostate Cancer Research Centre the Welcome Trust
- National Institute of Health Research-Health Technology Assessment Programme
- US National Institute of Health-National Cancer Institute
- UK National Institute of Health Research UCLH/UCL Comprehensive Biomedical Research Centre
- USHIFU
- GSK
- Advanced Medical Diagnostics
- Steba Biotech
- Oncura/GE Healthcare
- Medical Research Council [G1002509, G0701302, MR/M009092/1] Funding Source: researchfish
- National Institute for Health Research [DRF-2014-07-146, NF-SI-0514-10059] Funding Source: researchfish
- MRC [G0701302, G1002509, MR/M009092/1] Funding Source: UKRI
Focal therapy has increasingly become an accepted treatment option for patients with localised prostate cancer. Most follow-up protocols use a mixture of protocol biopsies or for cause biopsies triggered by a rising PSA. In this paper, we discuss the histological outcomes from these biopsies and their use in guiding subsequent management and trial development. We conducted a literature search and reviewed the post-treatment biopsy results from studies on focal HIFU and focal cryotherapy. We subsequently reviewed the results of three recently published consensus statements released discussing many of the issues concerning focal therapy. Research suggests that 1 in 5 of all post-treatment biopsies after focal therapy are positive. However, the majority of these seemed to be from the untreated portion of the gland or met criteria for clinically insignificant disease. The histological outcomes from focal therapy are promising and confirm its effectiveness in the short to medium term. Furthermore re-treatment is possible whilst maintaining a low-side-effect profile. Debate is ongoing about the clinical significance of various levels of residual disease after focal therapy and the exact threshold at which to call failure within a patient who has had focal therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据