期刊
WORLD JOURNAL OF UROLOGY
卷 33, 期 10, 页码 1495-1502出版社
SPRINGER
DOI: 10.1007/s00345-014-1464-5
关键词
Physical activity; Body mass index; Prostate cancer; Cohort study; Epidemiology
资金
- ICA AB
- Telefonaktiebolaget LM Ericsson
- Swedish Cancer Society [CAN 2012/591]
- Karolinska Institutet Distinguished Professor Award (H-OA) [2368/10-221]
- Minister of University and Research, Italy (RB) [PRIN 2009 X8YCBN]
- Stockholm County Council
- Karolinska Institutet
Physical activity and body mass index (BMI) are involved in prostate cancer etiology; possible biologic mechanisms include their effects on hormonal levels. Our aim was to investigate the relationship between physical activity, obesity, and prostate cancer. We followed a cohort of 13,109 Swedish men for 13 years and investigated the association of self-reported physical activity and BMI at baseline with prostate cancer incidence. We further analyzed whether BMI could modulate effects of physical activity. Occupational, recreational, and total physical activity were analyzed in relation to overall, localized, and advanced prostate cancer. During the study follow-up, we observed a total of 904 cases of prostate cancer (429 localized, 407 advanced, and 68 unclassified). High levels of occupational physical activity were associated with a nonsignificantly decreased risk of overall (HR 0.81, 95 % CI 0.61-1.07), localized (HR 0.75, 95 % CI 0.51-1.12), and advanced (HR 0.85, 95 % CI 0.55-1.31) prostate cancer. We found no association between high BMI and risk of prostate cancer incidence: We observed, however, a significant interaction between BMI and leisure physical activity. No association was confirmed between total physical activity and localized or advanced prostate cancer. The highest, relative to the lowest, level of occupational physical activity tended to be linked to a lower risk of prostate cancer, with a suggested dose-response relationship. We found no association between high BMI and risk of prostate cancer incidence; however, our analyses suggested an interaction between BMI and physical activity during recreational time that merits further investigation in future studies.
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