期刊
PLANTA MEDICA
卷 79, 期 15, 页码 1474-1479出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0033-1350805
关键词
Penicillium oxalicum; Trichocomaceae; dihydrothiophene-condensed chromone; cytotoxicity
资金
- NBRPC (973 Program) [2010CB833803]
- NMPWRPC [201305017]
- NHTRDPC (863 Program) [2012AA092104]
- NSFC [40931160435, 40976090, 20872151]
- CAS [KSCX2-EW-G-12B]
Two new dihydrothiophene-condensed chromones and a new natural chromone, namely oxalicumones A-C (1-3), respectively, were isolated from a culture broth of a marine-derived fungus, Penicillium oxalicum. The structures of 1-3 and acetylated derivatives of 1 (4-7) were elucidated on the basis of spectroscopic methods and chemical reactions. The absolute configuration of 1 and 2 were established by using the modified Mosher ester method and circular dichroism data of an in situ formed [Rh-2(OCOCF3)(4)] and [Mo-2(OAc)(4)] complex. (R)-MTPA ester of 1 showed cytotoxicity against A375, SW-620, and HeLa carcinoma cell lines with IC50 values of 8.9, 7.8, and 18.4 mu M, respectively. Compound 1 displayed cytotoxicity against A375 and SW-620 cell lines with IC50 values of 11.7 and 22.6 mu M, respectively. The structure-biological activity relationship of 1 was discussed.
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