期刊
PLANTA MEDICA
卷 78, 期 15, 页码 1636-1638出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0032-1315208
关键词
monoterpenoids; antiviral; herpes simplex virus type 1; thymol; carvacrol
资金
- National Science Council, Taiwan [NSC 95-2320-B-010-051-MY3]
This study examined the anti-herpes simplex virus type I activity of the major constituents of several essential oils. Plaque reduction assays were performed to evaluate anti-herpes simplex virus type I activity. Thymol and carvacrol both possessed significant antiviral activity with an IC50 of 7 mu M, and herpes simplex virus type I was 90% inactivated within 1 hr. The mode of antiviral action was shown to affect the virion directly. Evidence was also observed by electron microscopy. Evaluation of the structural requirements for antiviral activity of thymol-related monoterpenoids revealed that aliphatic side chains had a minor effect, while a hydrophilic group on the benzene ring was sufficient for activity. Our results suggest that thymol and carvacrol are potential candidates for topical therapeutic application to reduce herpes simplex virus transmission.
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