期刊
PLANTA MEDICA
卷 78, 期 12, 页码 1370-1377出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0032-1314975
关键词
Euphorbia neriifolia; Euphorbiaceae; cycloartane triterpene; ingol diterpene; death receptor; TRAIL
资金
- Japan Society for the Promotion of Science (JSPS)
- Special Funds for Education and Research (Development of SPECT Probes for Pharmaceutical Innovation) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan
- Iodine Research Project in Chiba University
- Asian Core Program (JSPS)
- Collaborative Research Program of the Institute for Chemical Research, Kyoto University [2010-35]
- Grants-in-Aid for Scientific Research [23404007, 22310133, 23102008] Funding Source: KAKEN
In our screening program for natural products that increase death-receptor 5 expression, seven new cycloartane triterpenes, euphonerins A-G (1-7), and 3-O-acetyl-8-O-tigloylingol (8), a new ingol diterpene, were isolated from the MeOH extract of Euphorbia neriifolia leaves, together with 3,12-di-O-acetyl-8-O-tigloylingol (9), (24R)-cycloartane-3 beta,24,25-triol (10), and three known flavonols (11-13). The structures of 1-8 were elucidated by spectroscopic analysis. Among these compounds, 1-11 showed death-receptor 5 expression enhancing activity.
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