期刊
PLANTA MEDICA
卷 78, 期 5, 页码 485-487出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1298215
关键词
Thuja orientalis; Cupressaceae; diterpene; cytotoxicity
资金
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [20100029358]
Three new diterpenoids, 18-formyloxy-8 beta-hydroxysandaracopimar-15-ene (1), 15(R)-n-butoxypinusolidic acid (2), and 15,16-dihydro-15,16-dimethoxylambertianic acid (3), along with twelve known compounds (4-15) were isolated from MeOH extracts of leaves of Thuja orientalis L. The structures of the three new compounds were elucidated on the basis of spectroscopic analyses, including extensive 2D-NMR data. The absolute stereochemistry of compound 2 was clarified by a CD spectroscopic study. The isolated compounds were evaluated for cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines in vitro using the sulforhodamin B (SRB) bioassay.
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