期刊
PLANTA MEDICA
卷 78, 期 12, 页码 1391-1394出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0032-1314980
关键词
Cimicifuga heracleifolia; Ranunculaceae; cycloartane glycoside; anticomplement activity
资金
- National Research Foundation of Korea
- Korean Government (MEST) [KRF-2009-0084675]
Seven known triterpene glycosides, 23-O-acetylshengmanol 3-O- alpha-L-arabinopyranoside (1), 23-O-acetylshengmanol 3-O-beta-D-xylopyranoside (2), 24-epi-24-O-acetylhydroshengmanol 3-O-beta-D- xylopyranoside (3), cimiaceroside B (4), (23R, 24S)-cimigenol 3-O-beta-D-xylopyranoside (5), (23R, 24R)-25-O-acetylcimigenol 3-O- beta-D-xylopyranoside (6) and (23R, 24S)-25-O-anhydrocimigenol 3-O-beta-D-xylopyranoside (7) were isolated from the rhizomes of Cimicifuga heracleifolia. Their chemical structures were determined on the basis of spectroscopic analyses including 2D NMR. All isolates were investigated for their inhibitory effects on the classical pathway of the complement system. Among them, compound 6 showed strong inhibitory activity with an IC50 value of 7.7 mu M while compound 3 was moderately active with an IC50 value of 195.6 mu M.
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