Sesquiterpenoids from the Root Tubers of Lindera aggregata

Six new sesquiterpenoids, linderanlide A-F (1-5 and 12), and nine previously reported sesquiterpenoids (6-11 and 13-15) have been isolated from the root tubers of Lindera aggregata. The new structures have been elucidated by extensive spectroscopic interpretation, including UV, IR, NMR, HR-ESI-MS, and CD spectra. The structures of compounds 1, 2, 6, 7, and 9 were further confirmed by single-crystal X-ray diffraction analysis. The absolute configurations of compounds 3-5 were determined by CD spectral analysis.