期刊
PLANTA MEDICA
卷 77, 期 9, 页码 929-933出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1250672
关键词
Agavaceae; Agave sisalana; steroidal saponin; MCF-7 cells; NCI-H460 cells; SF-268 cells
资金
- National Science Council of the Republic of China, Taiwan Department of Health Clinical Trial Research Center of Excellence [DOH99-TD-B-111-004]
- Health Cancer Research Center of Excellence [DOH99-TD-B-111-005]
Two new steroidal saponins, 8 and 10, along with 7 known steroidal sapogenins and saponins (1-7) and a furostanol saponin (9) were isolated from Agave sisalana Perrine ex Engelm. The structures of these two new compounds were identified and characterized by 1D and 2D NMR spectroscopy and mass spectrometry. In addition, acid hydrolysis and GC-FID were used to confirm the sugar moieties of 8 and 10. The cytotoxic effects of 1-10 on MCF-7, NCI-H460, and SF-268 cancer cells were evaluated, and among them, compound 10 proved to be the most cytotoxic with IC(50) values of 1.2, 3.8, and 1.5 mu M, respectively.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据