期刊
PLANTA MEDICA
卷 77, 期 18, 页码 2050-U102出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1280124
关键词
Strychnos usambarensis Gilg.; Loganiaceae; monomeric indole alkaloid; antiplasmodial; selectivity
资金
- Belgian National Fund for Scientific Research (FNRS) [3.4533.10]
- CUD (Cooperation Universitaire au Developpement)
In the course of our investigations on Strychnos usambarensis leaves in order to isolate isostrychnopentamine, the main alkaloid responsible for the antiplasmodial activity of the plant, a new tertiary indolic alkaloid has been isolated: 17-O-acetyl, 10-hydroxycorynantheol 1. Its structure was determined by means of spectroscopic and spectrometric methods such as UV, IR, CD, NMR, and ESI-MS. 17-O-acetyl, 10-hydroxycorynantheol 1 is one of the most active monomeric indole alkaloids known to date showing an in vitro activity against Plasmodium falciparum close to 5 mu M and a high selectivity.
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