期刊
PLANTA MEDICA
卷 77, 期 9, 页码 955-957出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1250665
关键词
Glechoma hederacea; Labiatae; sesquiterpene lactone; cytotoxicity
Three new sesquiterpene lactones, 1 alpha, 10 beta-epoxy-4-hydroxy-glechoma-5-en-olide (1), 1 beta, 10 alpha-epoxy-4,8-dihydroxy-glechoma-5-en-olide (2), and 1 beta, 10 alpha; 4 alpha, 5 beta-diepoxy-8-methoxy-glechoman-8 alpha, 12-olide (3), were isolated from the whole plant of Glechoma hederacea, together with four known sesquiterpene lactones. The structures of the three new sesquiterpene lactones were determined by spectroscopic evidence. Cytotoxic effects of the isolated compounds were examined against MDA-MB-231 (breast), HCT116 (colon), SW620 (colon), and DU145 (prostate) human cancer cell lines.
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