期刊
PLANTA MEDICA
卷 77, 期 15, 页码 1735-1738出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1271040
关键词
Trichosphaeriaceae; Nigrospora sp.; Kandelia candel (L.) Druce; metabolites; cytotoxicity; antimicrobial activity
资金
- National Natural Science Foundation of China [20972197]
- Natural Science Foundation of Guangdong province of China [9151027501000055]
- Science & Technology Plan Project of Guangdong Province of China [2010B030600004]
- University-industry cooperation projects of Guangdong Province
- Ministry of Education [2008B090500171]
- Guangzhou Project of Science & Technology Planning [2010J1-E331]
- Fundamental Research Funds for the Central Universities [11lgjc01]
- Prize Fund for Excellent Middle Aged and Young Scientists of Shandong Province [BS2009HZ004]
Two new compounds, methyl 3-chloro-6-hydroxy-2-(4-hydroxy-2-methoxy-6-methylphenoxy)-4-methoxybenzoate (1) and (2S,5'R,E)-7-hydroxy-4,6-dimethoxy-2-(1-methoxy-3-oxo-5-methylhex-1-enyl)-benzofuran-3(2H)-one (2), together with four known compounds, griseofulvin (3), dechlorogriseofulvin (4), bostrycin (5), and deoxybostrycin (6), were isolated from the marine endophytic fungus Nigrospora sp. (No. 1403) collected from the South China Sea. The structures were elucidated by spectroscopic methods, 1D, 2D NMR, and HREIMS. Compounds 5 and 6 showed moderate antitumor and moderate antimicrobial activity.
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