期刊
PLANTA MEDICA
卷 78, 期 1, 页码 36-38出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1280199
关键词
Deguelia rufescens var. urucu; Leguminosae; stilbenes; diabetes; alpha-glucosidase; plasma glucose
资金
- Fundacao de Apoio a Pesquisa do Estado de Minas Gerais (FAPEMIG)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
The control of blood glucose levels is critical in the treatment of diabetes mellitus. alpha-Glucosidase inhibitors are of great importance in reducing hyperglycemia, and plants have provided many of these agents. The present study aimed at investigating the effect of two stilbenes, lonchocarpene and 3,5-dimethoxy-4'-O-prenyl-trans-stilbene (DPS), isolated from the Amazonian plant Deguelia rufescens var. urucu, on alpha-glucosidase activity and on mice postprandial hyperglycemia. Lonchocarpene and DPS inhibited alpha-glucosidase in vitro, with pIC(50) values of 5.68 +/- 0.12 and 5.73 +/- 0.08, respectively. In addition, when given orally, DPS produced a significant reduction of hyperglycemia induced by an oral tolerance test, while lonchocarpene did not. Data suggest that DPS may have a potential use as an antidiabetic drug.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据