期刊
PLANTA MEDICA
卷 78, 期 2, 页码 172-176出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1280347
关键词
Xylaria sp.; Acanthus ilicifolius; L. Acanthaceae; mangrove fungus; lactone; electronic circular dichroism
资金
- China's Marine Commonwealth Research Project [201005022-2]
- 863 Foundation of China [2007AA09Z448]
- Fundamental Research Funds for the Central Universities [101gpy11]
- Syngenta Ltd.
Two new lactones, 1 and 2, together with five known compounds, 3-7, were isolated from the marine mangrove fungus Xylaria sp. BL321. Their structures were determined by comprehensive analysis of their MS and NMR spectroscopic data. The absolute configurations of 1 and 2 were established on the basis of electronic circular dichroism calculations. It was found that the exocyclic double bond of 1 rearranged into a cyclic double bond to form a new crystal compound (1a) in diluted NaOH solution. Compound 3 was isolated for the first time as a natural product; its absolute configuration was determined by single-crystal X-ray crystallography. Compounds 4-7 displayed cytotoxicity against human breast cancer cell lines MCF-7 and MDA-MB-435, while compounds 1-3 were inactive (IC50 > 50 mu M).
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