期刊
PLANTA MEDICA
卷 76, 期 10, 页码 998-1003出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1240869
关键词
Ligustrum lucidum; Oleaceae; secoiridoid glucosides; iso-oleonuezhenide; methyloleoside 7-ethyl ester; ERK; CREB
资金
- Area of Excellence Scheme, University Grants Committee of HKSAR [AoE/B-15/01, AoE/B-15/01-II]
Two new secoiridoid glucosides, namely iso-oleonuezhenide (1) and methyloleoside 7-ethyl ester (2), along with five known ones, oleonuezhenide (3), nuezhenide (4), oleuropein (5), G13 (6), and jaspolyside methyl ester (7), were isolated from the fruits of Ligustrum lucidum. Their structures were assigned based on H-1-NMR, C-13-NMR, and 2D-NMR analyses, in combination with HR-MS experiments and the comparison with literature data of related compounds, as well as on chemical experiments. We have examined the ability of these compounds to activate ERK and CREB in cultured cortical neurons. Our studies demonstrate that compound 1 induces ERK and CREB phosphorylation in primary cortical neurons in a dose- and temporal-dependent manner, suggesting its bioactivity on neurons.
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