期刊
PLANTA MEDICA
卷 76, 期 17, 页码 1987-1996出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1250520
关键词
traditional Chinese medicine; quality control; mid-infrared spectroscopy; two-dimensional correlation infrared spectroscopy; chemometric techniques
资金
- State Administration of Traditional Chinese Medicine of China [2001ZDZX01]
- Ministry of Science and Technology of China [2002BA906A29-4]
- Sichuan Provincial grant in China [04SG011-035-1, 2009FZ0053]
Chinese herbal medicines are often referred to as Chinese materia medica (CMM). Composite formulae containing mixtures of CMM are prescribed for treatment and prevention of diseases in the practice of traditional Chinese medicine (TCM). Some of the well-known CMM formulae (Fufang in Chinese) are manufactured and marketed as proprietary Chinese medicines (PCM). Quality assessment and assurance of these products are difficult; they are a challenging task. Mid-infrared spectroscopy, a classic molecular structure analysis method, has been innovatively applied in the quality control of TCM, and has gained significant impact and advancement in analytical fields. Infrared fingerprinting features appear particularly suitable for the identification of multicomponent matrices in samples whose chemical integrity has not been altered or destroyed because no extraction procedure is needed. This review summarizes and gives an overall view on the application of mid-infrared and two-dimensional correlation infrared (2D-IR) spectroscopy as well as chemometric techniques in the identification of CMM, investigation of TCM processing procedures, and analysis of herb extracts and preparations.
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