期刊
PLANTA MEDICA
卷 75, 期 12, 页码 1331-1335出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1185546
关键词
Ridolfia segetum; Oenanthe crocata; Apiaceae; essential oil; HIV-1 reverse transcriptase inhibition; K-562 cell; GC-MS analysis
资金
- Provincia dell'Ogliastra
The essential oils of Ridolfia segetum (L.) Moris and Oenanthe crocata L. (Apiaceae), collected in Sardinia (Italy), have been assayed for two enzyme-associated activities of the HIV-1 reverse transcriptase (RT): RNA-dependent DNA polymerase (RDDP) activity and ribonuclease H (RNase H) activity. In biochemical assays, the essential oils inhibited HIV-1 RT RDDP activity in a dose-dependent manner, while they were inactive towards RNase H activity. Furthermore, the oils were cytotoxic towards K-562 cell replication. GC-MS analysis of the essential oils obtained by steam distillation of the aerial parts showed that the main components of R. segetum were alpha-phellandrene, alpha-terpinolene, beta-phellandrene, and dillapiol and those of O. rocata were sabinene, trans-beta-ocimene, cis-beta-ocimene, and beta-pinene.
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