期刊
PLANTA MEDICA
卷 76, 期 7, 页码 726-728出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1240656
关键词
Anisochilus harmandii Doan; Lamiaceae; diterpene; antimalarial; antimycobacterial; cytotoxicity
资金
- Thailand Research Fund [PHD/0240/2549]
- Center for Innovation in Chemistry (PERCH-CIC), Ministry of Education, Thailand
- Khon Kaen University via the Natural Products Research Unit
- Commission on Higher Education (CHE-RESRG), Ministry of Education
Two new diterpenes, 4-epi-triptobenzene L (1) and 12-O-deacetyl- 6-O-acetyl-19-acetyloxycoleon Q (2), as well as eight known diterpenes (3-10) were isolated from the aerial parts of Anisochilus hamandii. Structures of the isolated compounds were identified from spectroscopic evidence. Compounds 1, 2, 5, and 10 exhibited antiplasmodial activity against Plasmodium falciparum (IC(50) 4.70, 2.90, 3.03, and 7.20 mu g/mL, respectively), while 3, 5, and 7 showed antimycobacterial activity against Mycobacterium tuberculosis (MIC 50 mu g/mL). In addition, only 10 showed strong cytotoxicity against NCI-H187 cells (IC(50) 4.43 mu g/mL).
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