Bioactive Diterpenes from the Aerial Parts of Anisochilus harmandii

Two new diterpenes, 4-epi-triptobenzene L (1) and 12-O-deacetyl- 6-O-acetyl-19-acetyloxycoleon Q (2), as well as eight known diterpenes (3-10) were isolated from the aerial parts of Anisochilus hamandii. Structures of the isolated compounds were identified from spectroscopic evidence. Compounds 1, 2, 5, and 10 exhibited antiplasmodial activity against Plasmodium falciparum (IC(50) 4.70, 2.90, 3.03, and 7.20 mu g/mL, respectively), while 3, 5, and 7 showed antimycobacterial activity against Mycobacterium tuberculosis (MIC 50 mu g/mL). In addition, only 10 showed strong cytotoxicity against NCI-H187 cells (IC(50) 4.43 mu g/mL).