期刊
PLANTA MEDICA
卷 74, 期 13, 页码 1656-1665出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0028-1088304
关键词
tamoxifen; raloxifene; phytoestrogens; SERMs; selective estrogen receptor modulators; breast cancer; chemoprevention
资金
- 5T32CA10365-03
- Department of Defense Breast Program [BC050277]
- SPORE
- NIH [P30 CA006927]
- Avon Foundation
- Weg Fund of Fox Chase Cancer Center
- NATIONAL CANCER INSTITUTE [P50CA089018, P30CA006927] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM061756] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH067156] Funding Source: NIH RePORTER
Scientific achievements in the last two decades have revolutionized the treatment and prevention of breast cancer. This is mainly because of targeted therapies and a better understanding of the relationship between estrogen, its receptor, and breast cancer. One of these discoveries is the use of synthetic selective estrogen modulators (SERMs) such as tamoxifen in the treatment strategy for estrogen receptor (ER)-positive breast cancer. Hundreds of thousands of lives have been saved because of this advance. Not only is tamoxifen used in the treatment strategy for patients who have breast cancer, but also for prevention in high-risk premenopausal women. Another synthetic SERM, raloxifene, which was initially used to prevent osteoporosis, is also as effective as tamoxifen for prevention in high-risk postmenopausal women. In certain regions of the world, particularly in Asia, a low incidence of breast cancer has been observed. These women have diets that are high in soy and low in fat, unlike the Western diet. Interest in the protective effects of soy derivatives has led to the research of phytoestrogens and metabolites of soy that are described by some as natural SERMs. As a result, many clinical questions have been raised as to whether phytoestrogens, which are also found in other natural foods, can protect against breast cancer. This article reviews the development and role of the more common SERMs, tarnoxifen and raloxifene. In addition, this paper will also highlight the emerging studies on phytoestrogens and their similarity and dissimilarity to SERMs.
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