期刊
PLANTA MEDICA
卷 75, 期 2, 页码 174-177出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0028-1088345
关键词
Stemonaceae (Stemono sessilifolia); protostemonamide; stemospironine; protostemonine; maistemonine; antitussive activity
资金
- Science and Technology Committee of Shanghai [036505003]
- Shanghai Municipal Education Commission [060Z013]
Protostemonamide (1), a new protostemonine-type alkaloid, and 12 known compounds were isolated from the roots of Stemona sessilifolia. Their structures were elucidated by 1 D and 2 D NMR spectral and other spectroscopic studies. The main alkaloidal constituents, protostemonine (2), stemospironine (4), and maistemonine (7), showed significant antitussive activity in a citric acid-induced guinea pig cough model following peripheral administration; stemonamine (11) had antitussive activity following i.c.v. administration.
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