期刊
PLANTA MEDICA
卷 74, 期 14, 页码 1709-1715出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0028-1088315
关键词
Calendula officinalis L.; Asteraceae; triterpenoids; oleanolic acid glycosides; antibacterial activity; parasitic nematodes
资金
- Ministry of Science and Higher Education grant [N 304 117 32/4332, BW1720/22]
The antibacterial and antiparasitic activities of free oleanolic acid and its glucosides and glucuronides isolated from marigold (Calendula officinalis) were investigated. The MIC of oleanolic acid and the effect on bacterial growth were estimated by A(600) measurements. Oleanolic acid's influence on bacterial survival and the ability to induce autolysis were measured by counting the number of cfu. Cell morphology and the presence of endospores were observed under electron and light rnicroscopy, respectively. Oleanolic acid inhibited bacterial growth and survival, influenced cell morphology and enhanced the autolysis Of Gram-positive bacteria Suggesting that bacterial envelopes are the target of its activity. On the other hand, glycosides of oleanolic acid inhibited the development of L(3) Heligmosomoides polygyrus larvae, the infective stage of this intestinal parasitic nematode. In addition, both oleanolic acid and its glycosides reduced the rate of L3 survival during prolonged storage, but only oleanolic acid a glucuronides affected nematode infectivity. The presented results Suggest that oleanolic acid and its glycosides can be considered as potential therapeutic agents.
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