Antimycobacterial substances from phaeoshpaeria sp BCC8292

Eleven substances including naphthalenones, naphthoquinones, unsymmetrical naphthoquinone dimers and a chlorinated cliphenyl ether, three of which are new, have been isolated from the fungus Phaeosphaeria sp.The absolute stereochernistry of naphthalenones has been determined by the Mosher and exciton chirality methods. The biological activity of these compounds against Mycobacterium tuberculosis and cytotoxicity against KB, BCA, NCI-H 187 and Vero cell lines were evaluated.