期刊
PLANTA MEDICA
卷 74, 期 2, 页码 147-150出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2008-1034293
关键词
Apiaceae; Ferula; anti-tumor promoting effect; terpenoid coumarins; Epstein-Barr virus activation assay; cancer chemoprevention
Several natural products have been found to have anti-tumor promoting activity. In the present study, we carried out a primary screening of ten terpenoid coumarins isolated from plants of the Ferula species, examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) in Raji cells. Auraptene (7-geranyloxycoumarin, 1) and umbelliprenin (7-farnesyloxycoumarin, 2) were found to significantly inhibit EBV-EA activation and pre-served the high viability of Raji cells, suggesting that they might be valuable anti-tumor-promoting agents IC50 8.3 and 9.1 nM, respectively). Our findings revealed that the presence of a prenyl moiety in the terpenoid coumarins plays an important role in anti-tumor promoting activity as previously reported for xanthones, coumarins, flavonoids and phenylpropanoids.
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