期刊
PLANT SCIENCE
卷 180, 期 4, 页码 584-603出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.plantsci.2010.12.008
关键词
Pathogen; Effector; Network; Systems biology; Modelling
资金
- Scottish Government Rural and Environmental Research and Analysis Directorate (RERAD)
- Biotechnology and Biological Sciences Research Council (BBSRC)
- Biotechnology and Biological Sciences Research Council [BB/G015244/1] Funding Source: researchfish
- BBSRC [BB/G015244/1] Funding Source: UKRI
Plants have biochemical defences against stresses from predators, parasites and pathogens. In this review we discuss the interaction of plant defences with microbial pathogens such as bacteria, fungi and oomycetes, and viruses. We examine principles of complex dynamic networks that allow identification of network components that are differentially and predictably sensitive to perturbation, thus making them likely effector targets. We relate these principles to recent developments in our understanding of known effector targets in plant-pathogen systems, and propose a systems-level framework for the interpretation and modelling of host-microbe interactions mediated by effectors. We describe this framework briefly, and conclude by discussing useful experimental approaches for populating this framework. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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