期刊
PLANT PHYSIOLOGY AND BIOCHEMISTRY
卷 46, 期 3, 页码 309-324出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.plaphy.2007.12.004
关键词
acetohydroxyacid synthase; branched-chain amino acids; herbicide; inhibitor; protein structure; herbicide resistance
Plants and microorganisms synthesize valine, leucine and isoleucine via a common pathway in which the first reaction is catalysed by acetohydroxyacid synthase (AHAS, EC 2.2.1.6). This enzyme is of substantial importance because it is the target of several herbicides, including all members of the popular sulfonylurea and imidazolinone families. However, the emergence of resistant weeds due to mutations that interfere with the inhibition of AHAS is now a worldwide problem. Here we summarize recent ideas on the way in which these herbicides inhibit the enzyme, based on the 3D structure of Arabidopsis thaliana AHAS. This structure also reveals important clues for understanding how various mutations can lead to herbicide resistance. (c) 2007 Elsevier Masson SAS. All rights reserved.
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