期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 21, 期 2, 页码 629-636出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v21.i2.629
关键词
Helicobacter pylori; Myanmar; Pepsinogen; Atrophy
资金
- National Institutes of Health [DK62813]
- Ministry of Education, Culture, Sports, Science and Technology of Japan [22390085, 22659087, 24406015, 24659200, 23790798]
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency
- Grants-in-Aid for Scientific Research [22390085, 26640114, 22659087, 24406015, 25860545, 23790798, 25293104, 24659200] Funding Source: KAKEN
AIM: To survey the detailed analyses for Helicobacter pylori (H. pylori) infection and gastric mucosal status in Myanmar. METHODS: A total of 252 volunteers with dyspeptic symptoms (155 female and 97 male; mean age of 43.6 +/- 14.2 years) was participated in Yangon and Mandalay. The status of H. pylori infection was determined based on 5 different tests including rapid urease test, culture, histology, immunohistochemistry and serology. Histological scores were evaluated according to the update Sydney system and the Operative Link for Gastritis Assessment system. Pepsinogen (PG). and PG. were measured using enzyme-linked immunosorbent assays. RESULTS: The overall prevalence of H. pylori infectionwas 48.0%. There was no relationship between age and infection rate. Even in young group (less than 29 years old), the H. pylori infection rate was relatively high (41.9%). The prevalence of H. pylori infection was significantly higher in Yangon than that of Mandalay. H. pylori infection was significantly associated with the presence of gastric mucosal atrophy. All 7 subjects with peptic ulcer were infected with H. pylori. Although H. pylori - positive subjects showed stronger gastritis than H. pylori - negative subjects, most cases had mild gastritis. CONCLUSION: We revealed the prevalence of H. pylori infection in patients with dyspeptic symptoms in Myanmar. The H. pylori infection was a risk factor for peptic ulcer and stronger gastritis.
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