期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 21, 期 36, 页码 10475-10479出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v21.i36.10475
关键词
Drug-induced liver injury; Masitinib; Amyotrophic lateral sclerosis; Tirosine kinase inhibitors; Autoimmunity; Autoimmune-like hepatitis; Idiosyncratic drug hepatotoxicity
资金
- Spanish Fondo de Investigaciones Sanitarias [PI13-01272]
- Interlaken Research Awards Program
We report a case of acute severe hepatitis resulting from masitinib in a young amyotrophic lateral sclerosis patient. Hepatotoxicity induced by masitinib, a tyrosine kinase inhibitor, is usually transient with mild elevation of transaminases, although acute hepatitis has been not reported to date. The hepatitis was resolved after masitinib was discontinued and a combination of prednisone and azathioprine was started. The transaminases returned to baseline normal values five months later. This is the first case in the hepatitis literature associated with masitinib. The autoimmune role of this drug-induced liver injury is discussed. Physicians should be aware of this potential complication.
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