期刊
PLANT JOURNAL
卷 78, 期 4, 页码 566-577出版社
WILEY
DOI: 10.1111/tpj.12516
关键词
guard cell; FAMA; FOUR LIPS; cell fate; stomatal development; Arabidopsis
资金
- Natural Sciences and Engineering Research Council of Canada
- Biotechnology and Biological Sciences Research Council
- Biotechnology and Biological Sciences Research Council [BB/H004319/1] Funding Source: researchfish
- BBSRC [BB/H004319/1] Funding Source: UKRI
Arabidopsis guard cell (GC) fate is conferred via a transient pulse of expression of FAMA that encodes a bHLH transcription factor. Stomata often function for years, suggesting that the FAMA expression window stabilizes long-term GC identity or that additional factors operate. Transgenic lines harboring a copy of a FAMA transgene were found to induce the fate resetting of mature GCs to that of lineage-specific stem cells causing new stomata to arise within shells of the old, a Stoma-in-Stoma (SIS) phenotype. These lines disrupt the normal trimethylation on lysine 27 of histone3 (H3K27me3) on stomatal stem cell genes, a phenotype rescued by constitutive expression of the Polycomb Group (PcG) gene CURLY LEAF. Thus the stability of stomatal fate is enforced by a PcG-mediated reduction in the transcriptional accessibility of stem cell genes and by the endogenous FAMA gene itself. Moreover, a transgenic FOUR LIPS gene, which encodes a MYB protein that is not required for GC fate, also induces a SIS phenotype and disrupts H3K27 trimethylation. Thus FLP might indirectly enforce GC fate as well.
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