期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 21, 期 48, 页码 13432-13437出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v21.i48.13432
关键词
Helicobacter pylori; Resistance; Eradication treatment; Triple antibiotic therapy; Gastrointestinal disease
资金
- Research Fund of Capital Medical Development [2005-1008]
Helicobacter pylori (H. pylori) infection is associated with a variety of upper gastrointestinal diseases, including gastric cancer. With the wide application of antibiotics in H. pylori eradication treatment, drug-resistant strains of H. pylori are increasing. H. pylori eradication treatment failure affects the outcome of a variety of diseases of the upper gastrointestinal tract. Therefore, antibiotic resistance that affects H. pylori eradication treatment is a challenging situation for clinicians. The ideal H. pylori eradication therapy should be safe, effective, simple, and economical. The eradication rate of triple antibiotic therapy is currently less than 80% in most parts of the world. Antibiotic resistance is the main reason for treatment failure, therefore the standard triple regimen is no longer suitable as a first-line treatment in most regions. H. pylori eradication treatment may fail for a number of reasons, including H. pylori strain factors, host factors, environmental factors, and inappropriate treatment.
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