期刊
PLANT FOODS FOR HUMAN NUTRITION
卷 64, 期 2, 页码 116-121出版社
SPRINGER
DOI: 10.1007/s11130-009-0112-5
关键词
Antiglycation; Antioxidant; Diabetes mellitus; Morus alba; Mulberry leaf
资金
- Faculty of Medicine and Graduate School, Khon Kaen University [i50111]
- Thailand Research Fund
In Thailand, beverages containing mulberry leaf (Morus alba L.) are believed to promote good health, especially in people with diabetes. We examined the effects of long-term administration of an ethanolic extract of mulberry leaf (MA) on blood glucose, oxidative damage, and glycation in streptozotocin-induced diabetic rats. Daily administration of 1 g/kg MA for six weeks decreased blood glucose by 22%, which was comparable to the effect of 4 U/kg insulin. Lipid peroxidation, measured as malondialdehyde and lipid hydroperoxide concentrations (3.50 +/- 0.33 and 3.76 +/- 0.18 mu M, respectively) decreased significantly (P < 0.05) compared to nontreated control diabetic rats (8.19 +/- 0.45 and 7.50 +/- 0.46 mu M, respectively). Hemoglobin A(1C), a biomarker for chronic exposure to high concentration of glucose, was also significantly decreased in the MA-treated group (6.78 +/- 0.30%) in comparison to untreated group (9.02 +/- 0.30%). The IC50 of in vitro antiglycation and free radical scavenging activities of MA were 16.4 +/- 5.6 mu g/ml and 61.7 +/- 2.1 mu g/ml, respectively. These findings support that long-term administration of MA has antihyperglycemic, antioxidant and antiglycation effects in chronic diabetic rats, which may be beneficial as food supplement for diabetics.
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