期刊
PLANT CELL
卷 26, 期 5, 页码 1981-1991出版社
AMER SOC PLANT BIOLOGISTS
DOI: 10.1105/tpc.114.124024
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资金
- National Basic Research Program of China (973 Program) [2012CB910900]
- National Institutes of Health [GM-47850]
- Peking-Tsinghua Center for Life Sciences
- Swedish Research Council
- Magnus Bergvalls Foundation
- Royal Physiographic Society in Lund
- Royal Swedish Academy of Agriculture and Forestry
- Adlerbert Research Foundation
- Olle Engkvist Byggmastare Foundation
- PA Larsson Foundation
- Wenner-Gren Foundation
- Next-Generation BioGreen 21 Program, Rural Development Administration, Republic of Korea [PJ00901003]
- National Genomics Infrastructure
- Science for Life Laboratory in Uppsala
CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) functions as an E3 ubiquitin ligase in both plants and animals. In dark-grown Arabidopsis thaliana seedlings, COP1 targets photomorphogenesis-promoting factors for degradation to repress photomorphogenesis. Little is known, however, about how COP1 itself is regulated. Here, we identify COP1 SUPPRESSOR1 (CSU1), a RING-finger E3 ubiquitin ligase, as a regulator of COP1. Genetic evidence demonstrates that csu1 mutations suppress cop1-6 phenotypes completely in the dark. Furthermore, CSU1 colocalizes with COP1 in nuclear speckles and negatively regulates COP1 protein accumulation in darkness. CSU1 can ubiquitinate COP1 in vitro and is essential for COP1 ubiquitination in vivo. Therefore, we conclude that CSU1 plays a major role in maintaining COP1 homeostasis by targeting COP1 for ubiquitination and degradation in dark-grown seedlings.
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