期刊
PLANT CELL
卷 24, 期 10, 页码 3859-3875出版社
OXFORD UNIV PRESS INC
DOI: 10.1105/tpc.112.100776
关键词
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资金
- Biotechnology and Biological Science Research Council David Phillips Fellowship [BB_BB/H022457/1]
- Marie Curie European Reintegration grant [PERG06-GA-2009-256354]
- Biotechnology and Biological Science Research Council-funded U.S. Partnering Award [BB/J020117/1]
- Birmingham Fellowship
- Marie Curie International Incoming Fellowship
- National Science Foundation- Integrative Organismal Systems [1052395]
- National Science Foundation [IOS-1026003, MCB-1052348, MCB-820823, DBI-640769]
- Swiss National Science Foundation
- Swedish Research Council
- Direct For Biological Sciences
- Div Of Biological Infrastructure [0640769] Funding Source: National Science Foundation
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1052395, 1026003] Funding Source: National Science Foundation
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1052348] Funding Source: National Science Foundation
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [0820823] Funding Source: National Science Foundation
Physiological responses, developmental programs, and cellular functions rely on complex networks of interactions at different levels and scales. Systems biology brings together high-throughput biochemical, genetic, and molecular approaches to generate omics data that can be analyzed and used in mathematical and computational models toward uncovering these networks on a global scale. Various approaches, including transcriptomics, proteomics, interactomics, and metabolomics, have been employed to obtain these data on the cellular, tissue, organ, and whole-plant level. We summarize progress on gene regulatory, cofunction, protein interaction, and metabolic networks. We also illustrate the main approaches that have been used to obtain these networks, with specific examples from Arabidopsis thaliana, and describe the pros and cons of each approach.
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