期刊
PLANT CELL
卷 20, 期 7, 页码 1915-1929出版社
AMER SOC PLANT BIOLOGISTS
DOI: 10.1105/tpc.108.058529
关键词
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资金
- Korea Research Foundation [KRF-2004037-C00254]
- National Institutes of Health [1R01 GM-068886]
- Terman Fellowship
- Hellman's Scholar Fellowship
We demonstrate that XopD, a type III effector from Xanthomonas campestris pathovar vesicatoria (Xcv), suppresses symptom production during the late stages of infection in susceptible tomato (Solanum lycopersicum) leaves. XopD-dependent delay of tissue degeneration correlates with reduced chlorophyll loss, reduced salicylic acid levels, and changes in the mRNA abundance of senescence- and defense-associated genes despite high pathogen titers. Subsequent structure-function analyses led to the discovery that XopD is a DNA binding protein that alters host transcription. XopD contains a putative helix-loop-helix domain required for DNA binding and two conserved ERF-associated amphiphilic motifs required to repress salicylic acid- and jasmonic acid-induced gene transcription in planta. Taken together, these data reveal that XopD is a unique virulence factor in Xcv that alters host transcription, promotes pathogen multiplication, and delays the onset of leaf chlorosis and necrosis.
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