期刊
PLANT CELL
卷 20, 期 12, 页码 3374-3388出版社
AMER SOC PLANT BIOLOGISTS
DOI: 10.1105/tpc.108.063859
关键词
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资金
- Ministerio de Educacion y Ciencia
- El Ministerio de Educacion y Ciencia [BIO2005-4733, BIO2008-1709]
- Bundesministerium fur Wirtschaft und Technologie via Deutsches Zentrum fur Luft und Raumfahrt [50WB0434]
- European Space Agency [AO-99-098]
- Ente Cassa di Risparmio di Firenze (Italy)
- [APVV-0432-06]
Plasma membrane repair in animal cells uses synaptotagmin 7, a Ca2+-activated membrane fusion protein that mediates delivery of intracellular membranes to wound sites by a mechanism resembling neuronal Ca2+-regulated exocytosis. Here, we show that loss of function of the homologous Arabidopsis thaliana Synaptotagmin 1 protein (SYT1) reduces the viability of cells as a consequence of a decrease in the integrity of the plasma membrane. This reduced integrity is enhanced in the syt1-2 null mutant in conditions of osmotic stress likely caused by a defective plasma membrane repair. Consistent with a role in plasma membrane repair, SYT1 is ubiquitously expressed, is located at the plasma membrane, and shares all domains characteristic of animal synaptotagmins (i.e., an N terminus-transmembrane domain and a cytoplasmic region containing two C2 domains with phospholipid binding activities). Our analyses support that membrane trafficking mediated by SYT1 is important for plasma membrane integrity and plant fitness.
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