期刊
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
卷 8, 期 4, 页码 619-630出版社
WILEY
DOI: 10.1002/wnan.1386
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资金
- University of Wisconsin - Madison
- National Institutes of Health [NIBIB/NCI R01CA169365, P30CA014520]
- American Cancer Society [125246-RSG-13-099-01-CCE]
- National Natural Science Foundation of China [51102131]
- National Natural Science Foundation of Jiangxi Province, China [20142BAB216033]
- Science without Borders Ph.D. Program scholarship from Brazil
Over the last decade, radiolabeled iron oxide nanoparticles have been developed as promising contrast agents for dual-modality positron emission tomography/magnetic resonance imaging (PET/MRI) or single-photon emission computed tomography/magnetic resonance imaging (SPECT/MRI). The combination of PET (or SPECT) with MRI can offer synergistic advantages for noninvasive, sensitive, high-resolution, and quantitative imaging, which is suitable for early detection of various diseases such as cancer. Here, we summarize the recent advances on radiolabeled iron oxide nanoparticles for dual-modality imaging, through the use of a variety of PET (and SPECT) isotopes by using both chelator-based and chelator-free radiolabeling techniques. (C) 2015 Wiley Periodicals, Inc.
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