期刊
PLANT AND CELL PHYSIOLOGY
卷 52, 期 1, 页码 30-36出版社
OXFORD UNIV PRESS
DOI: 10.1093/pcp/pcq146
关键词
Arabidopsis thaliana; CLV3; Peptide hormone; Structure-activity relationship
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [18101009]
- Program for Promotion of Basic Research Activities for Innovative Biosciences (PROBRAIN) of Japan
CLAVATA3 (CLV3) is a plant peptide hormone in which the proline residues are post-translationally hydroxylated and glycosylated. CLV3 plays a key role in controlling the stem cell mass in the shoot meristem of Arabidopsis thaliana. In a previous report, we identified a dodecapeptide (MCLV3) from CLV3-overexpressing Arabidopsis calli; MCLV3 was the smallest functional peptide derived from the CLV3 precursor. Here, we designed a series of MCLV3 analogs in which proline residues were substituted with proline derivatives or N-substituted glycines (peptoids). Peptoid substitution at Pro9 decreased bioactivity without affecting specific binding to the CLV1-related protein in cauliflower membrane. These findings suggest that peptoid-substituted peptides would be lead compounds for developing potential agonists and antagonists of CLV3.
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