期刊
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
卷 35, 期 4, 页码 779-782出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/ATVBAHA.114.304525
关键词
atherosclerosis; endothelium; glucocorticoid receptor
资金
- Charles H. Hood Foundation, Inc, Boston, MA
- Spanish Ministry (Programa Nacional de Movilidad de Recursos Humanos del Plan Nacional de I-D+i)
- National Institutes of Health (NIH) [HL117064]
- American Heart Association
- NIH [HL64793, HL61371, HL081190]
Objective-The purpose of this study was to determine the role of the endothelial glucocorticoid receptor in the pathogenesis of atherosclerosis. Approach and Results-Control mice and mice lacking the endothelial glucocorticoid receptor were bred onto an Apoe knockout background and subjected to high-fat diet feeding for 12 weeks. Assessment of body weight and total cholesterol and triglycerides before and after the diet revealed no differences between the 2 groups of mice. However, mice lacking the endothelial glucocorticoid receptor developed more severe atherosclerotic lesions in the aorta, brachiocephalic artery, and aortic sinus, as well as a heightened inflammatory milieu as evidenced by increased macrophage recruitment in the lesions. Conclusions-These data suggest that the endothelial glucocorticoid receptor is important for tonic inhibition of inflammation and limitation of atherosclerosis progression in this model.
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