期刊
PLACENTA
卷 35, 期 12, 页码 1099-1101出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2014.10.007
关键词
Preterm labour; Infection; High-throughput sequencing; 16S rDNA; Metagenetics; Placental membranes
资金
- SPARKS
- Action Medical Research [1791] Funding Source: researchfish
Infection is considered a possible trigger for preterm labour, supported by evidence showing the presence of bacteria in the placenta and placental membranes from preterm births. In this study, 16S rDNA pyrosequencing was used to identify bacteria in placental membranes. Caesarean sections and vaginal deliveries at term were found to harbour common genera. Mycoplasma hominis, Aerococcus christensenii, Gardnerella vaginalis and Fusobacterium nucleatum were either only present in preterm membranes or in greater abundance than at term. These data support previous studies that used either targeted qPCR or broad-range 16S rDNA PCR and cloning but not a recent microbiome analysis of placental tissue using high-throughput sequencing. (C) 2014 The Authors. Published by Elsevier Ltd.
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