期刊
PLACENTA
卷 35, 期 1, 页码 50-57出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2013.10.008
关键词
Periconceptional; Preimplantation; Ethanol; Placenta; Glycogen
资金
- National Health and Medical Research Council of Australia [1046137]
Introduction: Alcohol consumption is a common social practice among women of childbearing age. With 50% of pregnancies being unplanned, many embryos are exposed to alcohol prior to pregnancy recognition and formation of the placenta. The effects of periconceptional (PC) alcohol exposure on the placenta are unknown. Methods: Sprague-Dawley rats were exposed to alcohol (12.5% v/v ad libitum) from 4 days prior to 4 days after conception and effects on placental growth, morphology and gene/protein expression examined at embryonic day (E) 20. Results: PC ethanol (EtOH)-exposed fetuses were growth restricted and their placental/body weight ratio and placental cross-sectional area were increased. This was associated with an increase in cross-sectional area of the junctional zone and glycogen cells, especially in PC EtOH-exposed placentas from female fetuses. junctional Glut1 and Igf2 mRNA levels were increased. Labyrinth Igf1 mRNA levels were decreased in placentas from both sexes, but protein IGF1R levels were decreased in placentas from male fetuses only. Labyrinth mRNA levels of Slc38a2 were decreased and Vegfa were increased in placentas following PC EtOH-exposure but only placentas from female fetuses exhibited increased Kdr expression. Augmented expression of the protective enzyme 11 beta Hsd2 was found in PC EtOH-exposed labyrinth. Discussion: These observations are consistent with a stress response, apparent well beyond the period of EtOH-exposure and demonstrate that PC EtOH alters placental development in a sex specific manner. Conclusion: Public awareness should be increased to educate women about how excessive drinking even before falling pregnant may impact on placental development and fetal health. (C) 2013 Elsevier Ltd. All rights reserved.
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