期刊
PLACENTA
卷 35, 期 11, 页码 969-971出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2014.09.001
关键词
Mesenchymal stem cells; Fetal; Maternal; Placenta; Chorion; Decidua
资金
- National Health and Medical Research Council (NHMRC) [APP1023368]
The placenta is an abundant source of mesenchymal stem/stromal cells (MSC). Although presumed of translationally-advantageous fetal origin, the literature instead suggests a high incidence of either contaminating or pure maternal MSC. Despite definitional criteria that MSC are CD34, increasing evidence suggests that fetal MSC may be CD34 positive in vivo. We flow sorted term placental digests based on CD34+ expression and exploited differential culture media to isolate separately pure fetal and maternal MSC populations. This method has considerable translational implications, in particular to clinical trials underway with placental MSC of uncertain or decidual origin. (C) 2014 Elsevier Ltd. All rights reserved.
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