期刊
PLACENTA
卷 34, 期 11, 页码 1087-1090出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2013.09.006
关键词
Obesity; Fetal growth; Placenta
资金
- Tommy's
- Scottish Senior Clinical Fellowship
- MRC [G1002033] Funding Source: UKRI
- Chief Scientist Office [SCD/09] Funding Source: researchfish
- Medical Research Council [G1002033] Funding Source: researchfish
Exposure to overnutrition in utero may increase offspring cardiometabolic disease risk. A mouse model of maternal exposure to an obesogenic diet (DIO) was used to determine effects on fetal and placental weight and gene expression in mid- and late gestation. DIO altered placental gene expression in midgestation without differences in fetal or placental weights. Weight gain was attenuated in DIO dams in late gestation and male pup weight was reduced, however there were no persistent changes in placental gene expression. Differences in maternal weight gain and/or specific dietary components may impact on fetal and placental growth and later disease risk. (C) 2013 Elsevier Ltd. All rights reserved.
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