期刊
PLACENTA
卷 34, 期 8, 页码 716-718出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2013.05.005
关键词
Thyroid hormone; Transthyretin; Endocytosis
资金
- Queensland Health Smart State, Pathology Queensland
- Royal Brisbane and Women's Hospital Research Foundation
- Department of Endocrinology, Royal Brisbane and Women's Hospital
Normal fetal neurological development depends on a regulated supply of maternal thyroid hormone (TH). We have previously demonstrated that transthyretin (TTR) a TH binding protein, is synthesized, secreted and internalized by trophoblast cells and may provide a route for the transfer of TH from mother to fetus. Our objective was to determine if a member of the low-density lipoprotein receptor family mediates TTR or TTR-TH internalization. TTR-TH internalization by JEG-3 cells is reduced in the presence of receptor associated protein (RAP) or albumin suggesting that TTR-TH is internalized through an LDL-receptor dependent endocytic process. Crown Copyright (c) 2013 Published by Elsevier Ltd. All rights reserved.
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